Information on Oral Testosterone Therapy
Testosterone Replacement Therapy (TRT) has evolved from gels, patches, injections to oral formulations, offering patients another option.
This white paper summarizes answers to key questions addressed in a recently published review by Goldstein et al, Newer formulations of oral testosterone undecanoate: development and liver side effects. Sex Med Rev. 2025 Jan 31; 13(1):33‑40.
In this white paper, leading experts review breakthroughs in oral testosterone undecanoate (TU), including:
Liver safety: Clinical studies of oral TU formulations have consistently shown no clinically meaningful changes in liver function test results. No cases met Hy’s Law criteria, which are predictive of severe drug-induced liver injury (DILI). TLANDO is not a 17-alpha-alkyl androgen and is not known to produce hepatic adverse effects associated with 17-alpha-alkyl androgens. See hepatic adverse effects in the Prescribing Information for TLANDO.
Circumvention of first-pass liver metabolism: Oral TU’s are released into systemic circulation by the thoracic duct and converted to testosterone, predominantly avoiding absorption into the portal vein, and circumventing first-pass metabolism in the liver.
Enhanced absorption and bioavailability: Drug delivery systems used by TU formulations reduce reliance on high-fat meals for absorption.
Non-invasive alternative: Oral TU formulations offer a non-invasive alternative to injections and topical formulations, while eliminating the risk of transference.
Download the white paper to learn more about these oral TU formulations
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